fumonisin B2

Names

[ Name ]:
fumonisin B2

[Synonym ]:
fumonisin b2solution
FUMONISIN B3
FUMONISIN B2
EINECS 201-067-0
MFCD00133350
FB2,Fumonisin B2,Ready Made
Fumonisin B2 from Fusarium moniliforme
FB2
1,2,3-Propanetricarboxylic acid, 1,1'-[1-(12-amino-9,11-dihydroxy-2-methyltridecyl)-2-(1-methylpentyl)-1,2-ethanediyl] ester
2,2'-{(19-Amino-16,18-dihydroxy-5,9-dimethyl-6,7-icosanediyl)bis[oxy(2-oxo-2,1-ethanediyl)]}disuccinic acid
Diquat-d4 Dibromide

Biological Activity

[Description]:

Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[Target]

Sphingosine N-acyltransferase[2]

[References]

[1]. Henry MH, et al. The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. Poult Sci. 2001 Apr;80(4):401-7.

[2]. Shephard GS, et al. Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. Toxicon. 1996 May;34(5):527-34.

[3]. Wei T, et al. Natural occurrence of fumonisins B1 and B2 in corn in four provinces of China. Food Addit Contam Part B Surveill. 2013;6(4):270-4.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
864.4±65.0 °C at 760 mmHg

[ Melting Point ]:
<3200(dec)

[ Molecular Formula ]:
C₃₄H₅₉NO₁₄

[ Molecular Weight ]:
705.831

[ Flash Point ]:
476.6±34.3 °C

[ Exact Mass ]:
705.393555

[ PSA ]:
268.28000

[ LogP ]:
4.39

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.520

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ8335000

CHEMICAL NAME :: 1,2,3-Propanetricarboxylic acid, 1,1'-(1-(2-amino-9,11-dihydroxy-2-methyltridecyl)-2-( 1- methylpentyl)-1,2-ethanediyl) ester

CAS REGISTRY NUMBER :: 116355-84-1

LAST UPDATED :: 199510

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C34-H59-N-O14

MOLECULAR WEIGHT :: 705.94

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319

[ Precautionary Statements ]:
P210-P305 + P351 + P338-P370 + P378-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
R26/27/28

[ Safety Phrases ]:
S22;S45;S36/S37/S39

[ RIDADR ]:
UN 2811 6

[ WGK Germany ]:
3

[ RTECS ]:
TZ8335000

[ HS Code ]:
29221990

Articles

Lipid metabolism of commercial layers fed diets containing aflatoxin, fumonisin, and a binder.

Poult. Sci. 92(8) , 2077-83, (2013)

Aflatoxins (AF) and fumonisins (FU) are a major problem faced by poultry farmers, leading to huge economic losses. This experiment was conducted to determine the effects of AF (1 mg/kg of feed) and FU...

Surveys of rice sold in Canada for aflatoxins, ochratoxin A and fumonisins.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 28(6) , 767-74, (2011)

Approximately 200 samples of rice (including white, brown, red, black, basmati and jasmine, as well as wild rice) from several different countries, including the United States, Canada, Pakistan, India...

Assessment of fumonisins B1 and B2 levels in commercial maize-based food products by liquid chromatography with fluorimetric detection and postcolumn chemical derivatization.

J. Food Sci. 76(1) , T1-4, (2011)

The occurrence of the fumonisins B(1) and B(2) in maize-based food products marketed in Italy was examined. A simply and reliable chromatographic method with fluorimetric detection and postcolumn o-ph...