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ML 145

Names

[ CAS No. ]:
1164500-72-4

[ Name ]:
ML 145

[Synonym ]:
2-Hydroxy-4-[(4-{(5Z)-5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}butanoyl)amino]benzoic acid
Benzoic acid, 2-hydroxy-4-[[4-[(5Z)-5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxobutyl]amino]-
2-Hydroxy-4-[(4-{(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}butanoyl)amino]benzoic acid

Biological Activity

[Description]:

ML 145 is a selective GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM, but not for the related GPR55 orphan receptor[1]. GPR35 is expressed by various cells of the immune system and it may has potential as a therapeutic target in inflammatory disease[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

CXCR8:20.1 nM (IC50)


[References]

[1]. Heynen-Genel S, et al. Selective GPR35 Antagonists - Probes 1 & 2. National Center for Biotechnology Information (US); 2010-2010 Feb 28.

[2]. Binti Mohd Amir NAS, et al. Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35. J Immunol. 2018 Jul 15;201(2):714-724.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C24H22N2O5S2

[ Molecular Weight ]:
482.572

[ Exact Mass ]:
482.097015

[ LogP ]:
4.38

[ Index of Refraction ]:
1.719

Related Compounds