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3'-Methoxypuerarin

Names

[ CAS No. ]:
117047-07-1

[ Name ]:
3'-Methoxypuerarin

[Synonym ]:
3'-MethoxyPuerarin
1,3-DICAFFEOYLQUINIC ACID
(1S)-1,5-Anhydro-1-[7-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol
3-METHOXY PUERARIN
D-Glucitol, 1,5-anhydro-1-C-[7-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-4-oxo-4H-1-benzopyran-8-yl]-, (1S)-
Methoxypuerarin, 3'- '-

Biological Activity

[Description]:

3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease
Natural Products >> Flavonoids

[In Vivo]

3'-Methoxypuerarin increases the number of surviving neurons in the hippocampal CA1 region and markedly reduces the number of apoptotic pyramidal neurons after ischemia/reperfusion injury. 3'-Methoxypuerarin can protect hippocampal neurons against I/R injury by inhibiting apoptosis[1].

[Animal admin]

Rats[1] Male Wistar rats, weighing 260-320 g are randomly divided into three groups (n = 8 per group). [1] I/R+3'-MOP group: the rats undergo 8 minutes of ischemia and then 3 days of reperfusion. The 3'-Methoxypuerarin (60 mg/kg i.p.) is administrated at the moment of clamping of the carotid arteries. The rats receive daily i.p. injection of 3'-Methoxypuerarin for 3 days. [2] I/R group: the rats undergo 8 minutes of ischemia and 72 h of reperfusion. The same volume of solvent (35% polyethylene glycol solution) is administrated in the same way as 3'-Methoxypuerarin. [3] Control group: the rats undergo a sham operation. Vertebral and carotid arteries are exposed but not occluded. The rats receive a daily i.p. injection of 35% polyethylene glycol solution for 3 days[1].

[References]

[1]. Liu Y, et al. Protection by 3'-methoxypuerarin of rat hippocampal neurons against ischemia/reperfusion injury. Chin J Physiol. 2010 Apr 30;53(2):136-40.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
706.0±60.0 °C at 760 mmHg

[ Melting Point ]:
212-213℃

[ Molecular Formula ]:
C22H22O10

[ Molecular Weight ]:
446.404

[ Flash Point ]:
247.5±26.4 °C

[ Exact Mass ]:
446.121307

[ PSA ]:
170.05000

[ LogP ]:
1.72

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.696

[ Storage condition ]:
2-8℃

Related Compounds