hDHODH-IN-1

Names

[ CAS No. ]:
1173715-42-8

[ Name ]:
hDHODH-IN-1

Biological Activity

[Description]:

hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory effect[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase

Research Areas >> Inflammation/Immunology

[In Vitro]

Human dihydroorotate dehydrogenase (hDHODH) is a class-2 dihydroorotate dehydrogenase. Because DHODH is required to ensure proliferating-cell viability, inhibitors have been developed to eliminate human DHODH (hDHODH) activity, which is associated with cancers, multiple sclerosis, and autoimmune and inflammatory diseases[1].

[References]

[1]. Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₄N₂O₂

[ Molecular Weight ]:
278.31

hDHODH-IN-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds