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Acetylepipodophyllotoxin

Names

[ CAS No. ]:
1180-35-4

[ Name ]:
Acetylepipodophyllotoxin

[Synonym ]:
ethynyl-magnesium bromide
Ethynylmagnesium bromide solution
O-Acetyl-epipodophyllotoxin
Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-(acetyloxy)-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9S)-
acetylepipodophyllotoxin
ethynyl-MgBr
(5S,5aR,8aR,9R)-8-Oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl acetate
acetylenemagnesium bromide
acetylenyl magnesium bromide
bromomagnesium acetylide
epipodophyllotoxin acetate

Biological Activity

[Description]:

Epipodophyllotoxin acetate (4-O-Epipodophyllotoxinyl acetate; compound 4) is a cyclolignan that exhibits antineoplastic and antiviral activities. Epipodophyllotoxin acetate inhibits HSV and VSV, with IC50s of 0.2 and 0.1 μg/mL, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Anti-infection >> HSV
Research Areas >> Infection

[References]

[1]. Feliciano AS, et, al. Antineoplastic and antiviral activities of some cyclolignans. Planta Med. 1993 Jun;59(3):246-9.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
595.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H24O9

[ Molecular Weight ]:
456.44

[ Flash Point ]:
257.3±30.2 °C

[ Exact Mass ]:
456.142029

[ PSA ]:
98.75000

[ LogP ]:
2.03

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.613

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds