Duocarmycin A

Names

[ Name ]:
Duocarmycin A

[Synonym ]:
(+)-Dunnione
(+)-duocarmycin A

Biological Activity

[Description]:

Duocarmycin A, which is one of well-known antitumor antibiotics, efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

Signaling Pathways >> Apoptosis >> Caspase

[Target]

Procaspase-3

Caspase-9

[References]

[1]. Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₅N₃O₈

[ Molecular Weight ]:
507.49200

[ Exact Mass ]:
507.16400

[ PSA ]:
136.26000

[ LogP ]:
1.74720

Duocarmycin A

Names

Biological Activity

Chemical & Physical Properties

Related Compounds