2-Amino-6-chloropurine-9-beta-D-(2'-deoxy-3',5'-di-O-benzoyl-2'-fluoro)arabinoriboside

Names

[ Name ]:
2-Amino-6-chloropurine-9-beta-D-(2'-deoxy-3',5'-di-O-benzoyl-2'-fluoro)arabinoriboside

[Synonym ]:
2-amino-6-chloro-9-(2-deoxy-3,5-di-o-benzoyl-2-fluoro-b-d-arabinofuranosyl)purine

Biological Activity

[Description]:

2-Amino-6-chloropurine -9-beta-D-(2’-deoxy-3’,5’-di-O-benzoyl-2’-fluoro)arabinoriboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₁₉ClFN₅O₅

[ Molecular Weight ]:
511.89

[ Exact Mass ]:
511.10600

[ PSA ]:
131.45000

[ LogP ]:
3.96120

2-Amino-6-chloropurine-9-beta-D-(2'-deoxy-3',5'-di-O-benzoyl-2'-fluoro)arabinoriboside

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds