UNC-926

Names

[ CAS No. ]:
1184136-10-4

[ Name ]:
UNC-926

[Synonym ]:
UNC 926 hydrochloride
UNC-926

Biological Activity

[Description]:

UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; inhibits L3MBTL1 with an IC50 of 3.9 μM.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

[Target]

IC50: 3.9 μM (L3MBTL1)[1]

[In Vitro]

UNC-926 inhibits L3MBTL1 with an IC50 of 3.9 μM. L3MBTL1UNC-926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3, with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively inhibits the L3MBTL13xMBT-H4K20me1 interaction in a dose-dependent manner. UNC-926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC-926 for L3MBTL1 over 53BP1[1].

[References]

[1]. Herold JM, et al. Structure–activity relationships of methyl-lysine reader antagonists. MedChemComm. 2012;3(45):45–51.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₁BrN₂O

[ Molecular Weight ]:
337.25500

[ Exact Mass ]:
336.08400

[ PSA ]:
23.55000

[ LogP ]:
3.02530

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport