Ferric ammonium citrate

Names

[ Name ]:
Ferric ammonium citrate

[Synonym ]:
Ferric
EINECS 214-686-6
Iron(3+) 2-hydroxy-1,2,3-propanetricarboxylate ammoniate (1:1:1)
Ferricammoniumcitrae
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, ammonium iron(3+) salt (1:1:1)
MFCD00013099
Ammonium iron(III) citrate
Ammonium Ferric Citrate
Ammoniumironcitrate
IRON AMMONIUM CITRATE
Citric acid iron ammonium
Amonium Iron(III) Citrate Supplement
Ironandammoniumcit-rate
AmmoniumFerricCitrateUsp

Biological Activity

[Description]:

Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis[1]. Ammonium iron(III) citrate can enhance protein production[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> Ferroptosis

[In Vitro]

Ammonium iron(III) citrate (Ammonium ferric citrate; 1, 5, 10, 15 mM; 24 hours) with 5 mM induces cell death in HT1080 cells. AML12 cells were highly resistant to Ammonium iron(III) citrate, as they maintained cell viability about 80%. Ammonium iron(III) citrate can be actively transported into cells by specific transporter[1]. Ammonium iron(III) citrate (6, 12, 18 mg/L) has a higher biomas for Chlorella vulgaris FSP-E (CV) in BG-11 medium with 12 mg/L and 18 mg/L[2].

[References]

[1]. Shenglin Fang, et al. Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303.

[2]. Yu-Cheng Lai, et al. Towards protein production and application by using Chlorella species as circular economy. Bioresour Technol. 2019 Oct;289:121625.

Chemical & Physical Properties

[ Density]:
1.8 g/cm3 (20ºC)

[ Boiling Point ]:
197ºC

[ Molecular Formula ]:
C₆H₈FeNO₇

[ Molecular Weight ]:
261.975

[ Exact Mass ]:
261.965027

[ PSA ]:
102.37000

[ Water Solubility ]:
1200 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GE7540000

CHEMICAL NAME :: Citric acid, ammonium iron(3+) salt

CAS REGISTRY NUMBER :: 1185-57-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C6-H8-O7.xFe.xH4-N

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 9118

[ WGK Germany ]:
3

[ RTECS ]:
GE7540000

[ HS Code ]:
2918150000

Customs

[ HS Code ]: 2918150000

[ Summary ]:
2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%

Articles

Iron overload causes oxidative stress and impaired insulin signaling in AML-12 hepatocytes.

Dig. Dis. Sci. 58(7) , 1899-908, (2013)

Iron overload is associated with increased severity of nonalcoholic fatty liver disease (NAFLD) including progression to nonalcoholic steatohepatitis and hepatocellular carcinoma.To identify potential...

Effects of iron chelators, iron salts, and iron oxide nanoparticles on the proliferation and the iron content of oligodendroglial OLN-93 cells.

Neurochem. Res. 35(8) , 1259-68, (2010)

The oligodendroglial cell line OLN-93 was used as model system to investigate the consequences of iron deprivation or iron excess on cell proliferation. Presence of ferric or ferrous iron chelators in...

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter.

Gut 95 , 1261-8, (2010)

Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic i...