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Myelin Basic Protein (87-99) (human, bovine, rat)

Names

[ CAS No. ]:
118506-26-6

[ Name ]:
Myelin Basic Protein (87-99) (human, bovine, rat)

[Synonym ]:
h-val-his-phe-phe-lys-asn-ile-val-thr-pro-arg-thr-pro-oh
val-his-phe-phe-lys-asn-ile-val-thr-pro-arg-thr-pro
vhffknivtprtp

Biological Activity

[Description]:

Myelin Basic Protein(87-99) is an encephalitogenic peptide that induces basic protein-specific T cell proliferation. Myelin Basic Protein(87-99) causes a Th1 polarization in peripheral blood mononuclear cells with is implicated of multiple sclerosis (MS)[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. R E Jones, et al. The synthetic 87-99 peptide of myelin basic protein is encephalitogenic in Buffalo rats. J Neuroimmunol. 1992 Apr;37(3):203-12.

[2]. George Deraos, et al. Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP(87-99)) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: implications in triggering disease. J Med Chem. 2008 Dec 25;51(24):7834-42.

Chemical & Physical Properties

[ Molecular Formula ]:
C74H114N20O17

[ Molecular Weight ]:
1555.82000

[ Exact Mass ]:
1554.87000

[ PSA ]:
595.09000

[ LogP ]:
3.14350

Related Compounds