1'-Hydroxy bufuralol-d9

Names

[ Name ]:
1'-Hydroxy bufuralol-d9

[Synonym ]:
1'-Hydroxybufuralol-d9

Biological Activity

[Description]:

1'-Hydroxy bufuralol-d9 is a deuterium labeled 1'-Hydroxy bufuralol (HY-122277). 1'-Hydroxy bufuralol, the main metabolite of bufuralol, can reflect CYP2D activity[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.

[2]. Evangelos P Daskalopoulos, et al. D₂-dopaminergic receptor-linked pathways: critical regulators of CYP3A, CYP2C, and CYP2D. Mol Pharmacol. 2012 Oct;82(4):668-78.

[3]. H Yamazaki, et al. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Mol Pharmacol. 1994 Sep;46(3):568-77.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₄D₉NO₃

[ Molecular Weight ]:
286.41

[ Exact Mass ]:
286.22400

[ PSA ]:
65.63000

[ LogP ]:
3.29850