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Metformin D6 hydrochloride

Names

[ CAS No. ]:
1185166-01-1

[ Name ]:
Metformin D6 hydrochloride

[Synonym ]:
Metformin-(dimethyl-d6) hydrochloride
N,N-Bis[(H)methyl]imidodicarbonimidic diamide hydrochloride (1:1)
Imidodicarbonimidic diamide, N,N-dimethyl-d-, hydrochloride (1:1)
Diabex-d6,Glucophage-d6
Diabetosan-d6
Metformin-d6,Hydrochloride
N,N-Dimethylimidodicarbonimidic Diamide-d6,Hydrochloride
Metiguanide-d6

Biological Activity

[Description]:

Metformin D6 hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> PI3K/Akt/mTOR >> AMPK
Signaling Pathways >> Autophagy >> Mitophagy
Research Areas >> Metabolic Disease

[Target]

AMPK


[References]

[1]. Soraya H, et al. Acute treatment with metformin improves cardiac function following NSC 37745 induced myocardial infarction in rats. Pharmacol Rep. 2012;64(6):1476-84.

Chemical & Physical Properties

[ Melting Point ]:
215-218°C

[ Molecular Formula ]:
C4H6D6ClN5

[ Molecular Weight ]:
171.662

[ Exact Mass ]:
171.115784

[ PSA ]:
88.99000

[ LogP ]:
1.05850

[ Storage condition ]:
-20°C Freezer

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Related Compounds