TMN 355

Names

[ Name ]:
TMN 355

[Synonym ]:
2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide

Biological Activity

[Description]:

TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[Target]

cyclophilin A[1]

[In Vitro]

TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation[1]. Western Blot Analysis[1] Cell Line: THP cell lines Concentration: 0.5, 1, 2.5, 5 and 10 μM Incubation Time: 3, 6 and 9 hours Result: Resulted in 75.9% reduction of cyclophilin A protein expression.

[References]

[1]. Ramachandran S, et al. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15(1):152.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₄ClFN₂O₂

[ Molecular Weight ]:
380.79900

[ Exact Mass ]:
380.07300

[ PSA ]:
58.20000

[ LogP ]:
5.47030

Safety Information

[ Hazard Codes ]:
Xi

TMN 355

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds