Valecobulin
Names
Biological Activity
[Description]:
Valecobulin (CKD516), a valine prodrug of (S516) and a vascular disrupting agent (VDA), is a potent beta-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors[1][2].
[Related Catalog]:
[Target]
Beta-tubulin polymerization[1].
[In Vivo]
The size change of the tumor in VX2 liver tumor-bearing rabbits is significantly smaller in the Valecobulin (CKD516)( 5, 9, or 12 mg/m2, i.v.)- treated group than in control group[2]. Animal Model: VX2 liver tumor-bearing rabbits (Male New Zealand White rabbits weighing between 2.5 and 3.5 kg)[2]. Dosage: Dissolved in 5 mL of saline at a dose of 5, 9, or 12 mg/m2 of body surface area. Administration: Intravenous injection once. Result: The size change of the tumors was significantly smaller in the treated group than in control group.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C26H28N6O5S
[ Molecular Weight ]:
536.60300
[ Exact Mass ]:
536.18400
[ PSA ]:
175.21000
[ LogP ]:
4.91920