<Suppliers Price>

HO-PEG14-OH

Names

[ CAS No. ]:
1189112-05-7

[ Name ]:
HO-PEG14-OH

[Synonym ]:
PEG14
3,6,9,12,15,18,21,24,27,30,33,36,39-Tridecaoxahentetracontane-1,41-diol
MFCD09910394

Biological Activity

[Description]:

HO-PEG14-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
660.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C28H58O15

[ Molecular Weight ]:
634.751

[ Flash Point ]:
353.1±30.1 °C

[ Exact Mass ]:
634.377563

[ LogP ]:
-5.81

[ Vapour Pressure ]:
0.0±4.5 mmHg at 25°C

[ Index of Refraction ]:
1.466

Related Compounds