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Chlorothiazide-13C,15N2

Names

[ CAS No. ]:
1189440-79-6

[ Name ]:
Chlorothiazide-13C,15N2

[Synonym ]:
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide-13C,15N2 1,1-dioxide
Chlorothiazide-13C,15N2
Diuril-13C,15N2
6-Chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide-13C,15N2
Chlotride-13C,15N2
Chlorthiazide-13C,15N2
Saluric-13C,15N2

Biological Activity

[Description]:

Chlorothiazide-13C,15N2 is the 13C and 15N labeled Chlorothiazide[1]. Chlorothiazide is an orally active diuretic and anti-hypertensive agent[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Babu V R, et al. Preparation and in-vitro release of chlorothiazide novel pH-sensitive chitosan-N, N′-dimethylacrylamide semi-interpenetrating network microspheres. Carbohydrate Polymers, 2008, 71(2): 208-217.

Chemical & Physical Properties

[ Molecular Formula ]:
C7H6ClN3O4S2

[ Molecular Weight ]:
298.70300

[ Exact Mass ]:
297.94600

[ PSA ]:
135.45000

[ LogP ]:
2.56540

Related Compounds