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Guanfacine-13C,15N3

Names

[ CAS No. ]:
1189924-28-4

[ Name ]:
Guanfacine-13C,15N3

[Synonym ]:
Guarfacine-13C,15N3
Guanfacine-13C,15N3
Guanfacine0-13C,15N3
Guanfascine-13C,15N3

Biological Activity

[Description]:

Guanfacine-13C,15N3 is the 13C and 15N labeled Guanfacine[1]. Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD)[2][3][4].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Amy F T Arnsten, et al. Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale. Yale J Biol Med. 2012 Mar;85(1):45-58. Epub 2012 Mar 29.  

[3]. P. A. Van Zwieten, et al. The pharmacology of centrally acting antihypertensive drugs. Br J Clin Pharmacol. 1983 15(Suppl 4): 455S–462S.

[4]. Min Wang, et al. Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell. 2007 Apr 20129(2):397-410.  

Chemical & Physical Properties

[ Molecular Formula ]:
C9H9Cl2N3O

[ Molecular Weight ]:
250.06600

[ Exact Mass ]:
249.00700

[ PSA ]:
82.46000

[ LogP ]:
3.18590

Related Compounds