Efloxate

Names

[ CAS No. ]:
119-41-5

[ Name ]:
Efloxate

[Synonym ]:
Corosanin
Efloxatum
Recordil
Oxyflavil
[(4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]-acetic acid,ethyl ester
(4-Oxo-2-phenyl-4H-chromen-7-yloxy)-essigsaeure-aethylester
Coril
EINECS 204-321-9
Efloxate
(4-oxo-2-phenyl-4H-chromen-7-yloxy)-acetic acid ethyl ester
Angorlisin
Oxiflavil
Flacethyle
7-ethoxycarbonylmethoxyflavone
Domucor

Biological Activity

[Description]:

Efloxate is a vasodilator, used to treat chronic coronary insufficiency and Angina pectoris,

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cardiovascular Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.265g/cm3

[ Boiling Point ]:
486.5ºC at 760 mmHg

[ Melting Point ]:
123-124°

[ Molecular Formula ]:
C₁₉H₁₆O₅

[ Molecular Weight ]:
324.32700

[ Flash Point ]:
269.1ºC

[ Exact Mass ]:
324.10000

[ PSA ]:
65.74000

[ LogP ]:
3.40190

[ Vapour Pressure ]:
1.28E-09mmHg at 25°C

[ Index of Refraction ]:
1.59

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AJ1460000

CHEMICAL NAME :: Acetic acid, ((4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy)-, ethyl ester

CAS REGISTRY NUMBER :: 119-41-5

BEILSTEIN REFERENCE NO. :: 0313027

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H16-O5

MOLECULAR WEIGHT :: 324.35

WISWESSER LINE NOTATION :: T66 BO EVJ CR& IO1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,125,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,125,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,561,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,125,1982

Safety Information

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%