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Efloxate

Names

[ CAS No. ]:
119-41-5

[ Name ]:
Efloxate

[Synonym ]:
Corosanin
Efloxatum
Recordil
Oxyflavil
[(4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]-acetic acid,ethyl ester
(4-Oxo-2-phenyl-4H-chromen-7-yloxy)-essigsaeure-aethylester
Coril
EINECS 204-321-9
Efloxate
(4-oxo-2-phenyl-4H-chromen-7-yloxy)-acetic acid ethyl ester
Angorlisin
Oxiflavil
Flacethyle
7-ethoxycarbonylmethoxyflavone
Domucor

Biological Activity

[Description]:

Efloxate is a vasodilator, used to treat chronic coronary insufficiency and Angina pectoris,

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cardiovascular Disease

[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.265g/cm3

[ Boiling Point ]:
486.5ºC at 760 mmHg

[ Melting Point ]:
123-124°

[ Molecular Formula ]:
C19H16O5

[ Molecular Weight ]:
324.32700

[ Flash Point ]:
269.1ºC

[ Exact Mass ]:
324.10000

[ PSA ]:
65.74000

[ LogP ]:
3.40190

[ Vapour Pressure ]:
1.28E-09mmHg at 25°C

[ Index of Refraction ]:
1.59

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AJ1460000
CHEMICAL NAME :
Acetic acid, ((4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy)-, ethyl ester
CAS REGISTRY NUMBER :
119-41-5
BEILSTEIN REFERENCE NO. :
0313027
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C19-H16-O5
MOLECULAR WEIGHT :
324.35
WISWESSER LINE NOTATION :
T66 BO EVJ CR& IO1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,125,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,125,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,561,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,125,1982

Safety Information

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%