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Besipirdine

Names

[ CAS No. ]:
119257-34-0

[ Name ]:
Besipirdine

[Synonym ]:
UNII-95PY16J933
N-(n-propyl)-N-(4-pyridinyl)-1H-indol-1-amine
N-propy-N-(4-pyridinyl)-1H-indol-1-amine
N-propyl-N-(pyridin-4-yl)-N-1H-indolyl-1-amine
1-(propyl-4-pyridylamino)indole
Besipirdine
Besipirdine [INN]
1H-Indol-1-amine,N-propyl-N-4-pyridinyl-,monohydrochloride
N-propyl-N-4-pyridinyl-1H-indol-1-amine

Biological Activity

[Description]:

Besipirdine is a non-receptor-dependent cholinomimetic agent with noradrenergic activity. Besipirdine inhibits voltage-dependent sodium and potassium channels.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Neurological Disease

[References]

[1]. Hsu RS, DiLeo EM, Chesson SM, Klein JT, Effland RC. Determination of HP 749, a potential therapeutic agent for Alzheimer's disease, in plasma by high-performance liquid chromatography. J Chromatogr. 1991;572(1-2):352-359.

[2]. Tang L, Smith CP, Huger FP, Kongsamut S. Effects of besipirdine at the voltage-dependent sodium channel. Br J Pharmacol. 1995;116(5):2468-2472.

Chemical & Physical Properties

[ Density]:
1.09g/cm3

[ Boiling Point ]:
405.9ºC at 760 mmHg

[ Molecular Formula ]:
C16H17N3

[ Molecular Weight ]:
251.32600

[ Flash Point ]:
199.3ºC

[ Exact Mass ]:
251.14200

[ PSA ]:
21.06000

[ LogP ]:
3.71600

[ Vapour Pressure ]:
8.49E-07mmHg at 25°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds