Rocuronium bromide

Names

[ CAS No. ]:
119302-91-9

[ Name ]:
Rocuronium bromide

[Synonym ]:
RocuroniuM BroMide IsoMers
(2β,3α,5α,16β,17β)-17-(acetyloxy)-3-hydroxy-2-morpholin-4-yl-16-(1-prop-2-en-1-ylpyrrolidinium-1-yl)androstane bromide
(2β,3α,5α,16β,17β)-17-(acetyloxy)-3-hydroxy-2-(morpholin-4-yl)-16-[1-(prop-2-en-1-yl)pyrrolidinium-1-yl]androstane bromide
(2β,3α,5α,16β,17β)-17-Acetoxy-16-(1-allyl-1-pyrrolidiniumyl)-3-hydroxy-2-(4-morpholinyl)androstane bromide
Rocuronium bromide
EINECS 214-776-5
androstane-3,17-diol, 2-(4-morpholinyl)-16-[1-(2-propenyl)-1-pyrrolidiniumyl]-, bromide, 17-acetate, (2β,3α,5α,16β,17β)-
Esmeron
(+)-Rocuronium bromide
Org-9426
(2β,3α,5α,16β,17β)-17-Acetoxy-16-(1-allylpyrrolidinium-1-yl)-3-hydroxy-2-(morpholin-4-yl)androstane bromide
Pyrrolidinium
Androstane-3,17-diol, 2-(4-morpholinyl)-16-[1-(2-propen-1-yl)-1-pyrrolidiniumyl]-, bromide, 17-acetate, (2β,3α,5α,16β,17β)- (1:1)
Eslax
Zemuron,Esmeron
MFCD00867768
ROCURONIUN BROMIDE
1-((2b,3a,5a,16b,17b)-17-(acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl)-1-(2-propenyl)pyrrolidinium bromide
Pyrrolidinium, 1-((2β,3α,5α,16β,17β)-17-(acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl)-1-(2-propenyl)-, bromide
Zemuron

Biological Activity

[Description]:

Rocuronium Bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation.IC50 Value:in vitro: Rocuronium reduced the indirectly elicited twitch tensions in normal (50% inhibitory concentration [IC(50)], 9.84 [9.64-10.04] μM, mean [95% confidence interval]) and all pretreated diaphragms (P < .01, n = 6) in a concentration-dependent fashion [1]. The ED95 of rocuronium is essentially the same for children as for adults. Its duration of action is similar to vecuronium, and it is shorter for children than for adults. Rocuronium is readily reversed with conventional doses of cholinesterase-inhibiting drugs [2]. Onset time until maximum block, duration until 25% recovery of twitch height, and recovery from 25 until 75% of twitch height were 1.7 (32), 53 (19) and 20 (37) min, respectively [3].in vivo: Only 8.7 +/- 5.7% (SD) and 6.0 +/- 2.8% of an injected dose of ORG 9426 and ORG 9616 was excreted into the urine, respectively. Conversely, 54.4 +/- 9.2% and 52.4 +/- 9.2% of an injected dose of ORG 9426 and 35.7 +/- 12.2% and 46.8 +/- 9.7% of ORG 9616 were excreted into the bile in cats without and with renal pedicle ligation, respectively [4].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Narimatsu E, Niiya T, Takahashi K, Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependentfashion. Am J Emerg Med. 2012 Jul;30(6):901-7.

[2]. Wicks TC. The pharmacology of rocuronium bromide (ORG 9426). AANA J. 1994 Feb;62(1):33-8.

[3]. Wierda JM, Kleef UW, Lambalk LM, The pharmacodynamics and pharmacokinetics of Org 9426, a new non-depolarizing neuromuscular blocking agent, in patients anaesthetized with nitrous oxide, halothane and fentanyl. Can J Anaesth. 1991 May;38(4 Pt 1):430-5.

[4]. Khuenl-Brady K, Castagnoli KP, Canfell PC, The neuromuscular blocking effects and pharmacokinetics of ORG 9426 and ORG 9616 in the cat. Anesthesiology. 1990 Apr;72(4):669-74.

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
162-1640C

[ Molecular Formula ]:
C₃₂H₅₃BrN₂O₄

[ Molecular Weight ]:
609.678

[ Exact Mass ]:
608.318848

[ PSA ]:
59.00000

[ LogP ]:
1.30820

[ Storage condition ]:
Room temp

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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