LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2

Names

[ CAS No. ]:
119386-39-9

[ Name ]:
LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2

[Synonym ]:
MYOSIN KINASE INHIBITING PEPTIDE
Myosin Light Chain Kinase Fragment 11-19 amide
LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-AMIDE
LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2
KKRAARATS-NH2
myosin light chain kinase fragment 11-19 amide
MYOSIN LIGHT CHAIN KINASE (11-19) AMIDE

Biological Activity

[Description]:

Myosin light chain kinase fragment 11-19 amide (MLCK(11-19) amide) is a substrate-specific peptide inhibitor of MLCK. Myosin light chain kinase fragment 11-19 amide inhibits hypotonicity-induced Ca2+ entry. Myosin light chain kinase fragment 11-19 amide can be used in the research of human cervical cancer[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

MLCK[1]

[In Vitro]

Myosin light chain kinase fragment 11-19 amide (5 μM) reduces the amplitude and rate of activation of noradrenaline-evoked non-selective cation current (Icat) in rabbit portal vein myocytes[1]. Myosin light chain kinase fragment 11-19 amide inhibits swelling-activated taurine transport with an IC50 value of 2.0 µM[2]. Myosin light chain kinase fragment 11-19 amide (10 µM) inhibits β2-integrin-mediated adhesion in neutrophils treated with KT5720 (25 µM)[3].

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₇₈N₁₈O₁₁

[ Molecular Weight ]:
987.16100

[ Exact Mass ]:
986.61000

[ PSA ]:
518.21000

[ LogP ]:
0.20500

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Minimum requirements for inhibition of smooth-muscle myosin light-chain kinase by synthetic peptides.

Biochem. J. 257 , 73, (1989)

Although the amino acid residues that are important for peptide substrates of myosin light-chain kinase have been reported, those that are important for peptide inhibitors of this enzyme have not prev...

Smooth muscle myosin kinase requires residues on the COOH-terminal side of the phosphorylation site. Peptide inhibitors.

J. Biol. Chem. 261 , 25, (1986)

The COOH-terminal residue in peptide analogs of the phosphorylation site sequence in smooth muscle myosin light chains, Lys11-Lys12-Arg13-Ala-Ala-Arg16-Ala-Thr-Ser19 -(P)Asn20-Val21-Phe22-Ala23, were ...

Rabbit skeletal muscle myosin light chain kinase. The calmodulin binding domain as a potential active site-directed inhibitory domain.

J. Biol. Chem. 262 , 11958-11963, (1987)

A synthetic peptide modeled after the calmodulin (CaM)-binding domain of rabbit skeletal muscle myosin light chain kinase, Lys-Arg-Arg-Trp-Lys5-Lys-Asn-Phe-Ile-Ala10-Val-Ser-Ala-Ala-+ ++Asn15-Arg-Phe-...