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Loureirin A

Names

[ CAS No. ]:
119425-89-7

[ Name ]:
Loureirin A

[Synonym ]:
3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one
3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone
1-Propanone, 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)-

Biological Activity

[Description]:

Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.

[Related Catalog]:

Natural Products >> Flavonoids
Research Areas >> Cardiovascular Disease

[Target]

Akt


[In Vitro]

Loureirin A (50 μM, 100 μM) inhibits collagen-induced platelet ATP secretion and thrombin-stimulated P-selectin expression in a dose-dependent manner. Loureirin A also significantly impairs platelet spreading on immobilized fibrinogen. Loureirin A almost completely eliminates collagen-induced Akt phosphorylation at Ser473 at the dose of 100 μM, and has an additive inhibitory effect with the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets at 50 μM[1].

[References]

[1]. Hao HZ, et al. Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies. Eur J Pharmacol. 2015 Jan 5;746:63-9.


[Related Small Molecules]

SB203580 | MK-2206 2HCl | SC79 | Capivasertib (AZD5363) | Honokiol | AKT inhibitor VIII | GDC-0068 | GSK690693 | Uprosertib | 1,3-Dicaffeoylquinic acid | TIC10 | Triciribine | Perifosine (KRX-0401) | afuresertib | A-443654

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
479.1±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H18O4

[ Molecular Weight ]:
286.322

[ Flash Point ]:
175.8±20.8 °C

[ Exact Mass ]:
286.120514

[ PSA ]:
55.76000

[ LogP ]:
3.30

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.573

[ Storage condition ]:
2-8C

Related Compounds