p-Hydroxymandelic acid

Names

[ Name ]:
p-Hydroxymandelic acid

[Synonym ]:
EINECS 214-839-7
4-Hydroxyphenylglycolic Acid
P-Hydroxy Mandelic Acid
2-Hydroxy-2-(4-hydroxyphenyl)acetic acid
MFCD00004234

Biological Activity

[Description]:

p-Hydroxymandelic acid is a valuable aromatic fine chemical and widely used for production of pharmaceuticals and food additives.

[Related Catalog]:

Research Areas >> Others

Natural Products >> Acids and Aldehydes

[Target]

Human Endogenous Metabolite

[In Vitro]

p-Hydroxymandelic acid (4-Hydroxymandelic acid; 4-HMA) is widely used in production of aromatic drugs and flavors. It is employed for the preparation of 4-hydroxyphenylacetic acid, which is the synthetic precursor of selective β1-receptor antagonist drug atenolol. p-Hydroxymandelic acid can conjugate cytotoxic drug and enzyme substrate, and such a p-Hydroxymandelic acid based adaptor system showed promising application in the targeting drug delivery system[1].

[References]

[1]. Li FF, et al. Engineering Escherichia coli for production of 4-hydroxymandelic acid using glucose-xylosemixture. Microb Cell Fact. 2016 May 27;15:90.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.48 g/cm3

[ Boiling Point ]:
405.4ºC at 760 mmHg

[ Melting Point ]:
82-85 °C(lit.)

[ Molecular Formula ]:
C₈H₈O₄

[ Molecular Weight ]:
168.14700

[ Flash Point ]:
213.1ºC

[ Exact Mass ]:
168.04200

[ PSA ]:
77.76000

[ LogP ]:
0.51020

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ HS Code ]:
2918290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%