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Propargyl-PEG6-NH2

Names

[ CAS No. ]:
1198080-04-4

[ Name ]:
Propargyl-PEG6-NH2

[Synonym ]:
3,6,9,12,15,18-Hexaoxaheneicos-20-yn-1-amine
3,6,9,12,15,18-Hexaoxahenicos-20-yn-1-amine

Biological Activity

[Description]:

Propargyl-PEG6-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
401.8±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H29NO6

[ Molecular Weight ]:
319.394

[ Flash Point ]:
190.0±21.0 °C

[ Exact Mass ]:
319.199493

[ LogP ]:
-1.89

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.465

Related Compounds