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(5Z)-2-amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one

Names

[ CAS No. ]:
1198098-03-1

[ Name ]:
(5Z)-2-amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one

[Synonym ]:
4(5H)-Thiazolone, 2-amino-5-[(3,4-dimethoxyphenyl)methylene]-, (5Z)-
5-(3,4-Dimethoxy-benzylidene)-2-imino-thiazolidin-4-one
(5Z)-2-Amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one

Biological Activity

[Description]:

GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC50 value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3
Research Areas >> Neurological Disease
Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

GSK-3β:80.5 nM (IC50)


[References]

[1]. Arfeen M, et al. Design, synthesis and biological evaluation of 5-benzylidene-2-iminothiazolidin-4-ones as selective GSK-3β inhibitors. Eur J Med Chem. 2016 Oct 4;121:727-736.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
454.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H12N2O3S

[ Molecular Weight ]:
264.300

[ Flash Point ]:
228.9±31.5 °C

[ Exact Mass ]:
264.056854

[ LogP ]:
1.73

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.630

[ Storage condition ]:
-20°C

Related Compounds