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Sodium Channel inhibitor 1

Names

[ CAS No. ]:
1198117-23-5

[ Name ]:
Sodium Channel inhibitor 1

[Synonym ]:
FD5015
Sodium Channel inhibitor 1

Biological Activity

[Description]:

Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment. IC50 Value: 0.16 uM ( Na v1.7, V hold-90mV); 0.41 uM (Na v1.7, V hold-90mV) [1]Target: Na v1.7Sodium Channel inhibitor1 demonstrated concentration-dependent efficacy in preclinical behavioral pain models.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Neurological Disease

[References]

[1]. Macsari I, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55(15):6866-80.


[Related Small Molecules]

EIPA | Riluzole | Ginsenoside Rg3 | Cariporide | Eleclazine hydrochloride | GS967 | Tenapanor | Triamterene | Ranolazine dihydrochloride | PF 05089771 | flecainide acetate | A-803467 | CNV1014802 (hydrochloride) | Zonisamide | Cinchocaine

Chemical & Physical Properties

[ Molecular Formula ]:
C24H19F4N3O3

[ Molecular Weight ]:
473.42000

[ Exact Mass ]:
473.13600

[ PSA ]:
75.02000

[ LogP ]:
4.95350

[ Storage condition ]:
2-8℃

Related Compounds