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N-(2-Phenoxyacetyl)guanosine

Names

[ CAS No. ]:
119824-66-7

[ Name ]:
N-(2-Phenoxyacetyl)guanosine

[Synonym ]:
N2-phenoxyacetylguanosine
2-N-phenoxyacetylguanosine
2-N-(phenoxyacetyl)guanosine
N2-(phenoxyacetyl)guanosine
N-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-2-phenoxy-acetamide

Biological Activity

[Description]:

N2-Phenoxyacetylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.  

Chemical & Physical Properties

[ Density]:
1.76±0.1 g/cm3(Predicted)

[ Melting Point ]:
159-160 °C

[ Molecular Formula ]:
C18H19N5O7

[ Molecular Weight ]:
417.37

[ Exact Mass ]:
417.12800

[ PSA ]:
171.82000

[ Storage condition ]:
2-8℃

Related Compounds