[(E)-(1-methylpyridin-2-ylidene)methyl]-oxo-azanium; sulfooxymethane
Names
[ CAS No. ]:
1200-55-1
[ Name ]:
[(E)-(1-methylpyridin-2-ylidene)methyl]-oxo-azanium; sulfooxymethane
[Synonym ]:
2-Formyl-1-methylpyridinium methyl sulfate oxime
Sulfomethylate de pralidoxime [French]
Contrastigmine
2-[(hydroxyimino)methyl]-1-methylpyridinium methyl sulfate
Pralidoxime methyl sulfate
Pyridinium,2-formyl-1-methyl-,methyl sulfate,oxime
Pyridine-2-aldoxime methylsulfate
Contrastigmin
EINECS 214-852-8
Chemical & Physical Properties
[ Boiling Point ]:
189.7ºC at 760 mmHg
[ Molecular Formula ]:
C8H12N2O5S
[ Molecular Weight ]:
248.25600
[ Flash Point ]:
68.5ºC
[ Exact Mass ]:
248.04700
[ PSA ]:
111.28000
[ LogP ]:
0.49300
[ Vapour Pressure ]:
0.562mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UU4582000
- CHEMICAL NAME :
- Pyridinium, 2-formyl-1-methyl-, methyl sulfate, oxime
- CAS REGISTRY NUMBER :
- 1200-55-1
- LAST UPDATED :
- 198611
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C7-H9-N2-O.C-H3-O4-S
- MOLECULAR WEIGHT :
- 248.28
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1716 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 15,1146,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 145 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 8,313,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 686 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 15,1146,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 172 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 15,1146,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 172 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 15,1146,1960
Safety Information
[ HS Code ]:
2933399090
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%