Insulin peglispro

Names

[ CAS No. ]:
1200440-65-8

[ Name ]:
Insulin peglispro

Biological Activity

[Description]:

Insulin peglispro (BIL) is a basal insulin with a flat, prolonged activity profile. Insulin peglispro can exhibit better glycaemic control compared to conventional insulins[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor

[In Vivo]

Insulin peglispro (BIL) (s.c., 17, 0.45 or 1.15 mg/kg/d, 52 week) 在任何剂量下对Crl:CD(SD)大鼠的生存没有影响，会导致体重有些增加。在给药剂量为 0.17 mg/kg时，血清葡萄糖浓度没有影响，而 0.45 mg/kg 时，在第 1 天给药后 3 小时和 6 小时显示出较低的血清葡萄糖浓度[1]。

[References]

[1]. Richard A Byrd, et al. Chronic Toxicology Studies of Basal Insulin Peglispro in Rats and Dogs: A Novel, PEGylated Insulin Lispro Analog with a Prolonged Duration of Action. Toxicol Pathol. 2017 Apr;45(3):402-415.   

Chemical & Physical Properties

[ Molecular Formula ]:
C370H566N104O110S4

[ Molecular Weight ]:
8359.32

Related Compounds