CRF (6-33)

Names

[ CAS No. ]:
120066-38-8

[ Name ]:
CRF (6-33)

[Synonym ]:
MFCD00671436

Biological Activity

[Description]:

CRF(6-33)(human) is a CRF binding protein (CRF-BP) ligand inhibitor. CRF(6-33)(human) competitively binds the CRF-BP but not the post-synaptic CRF receptors. CRF(6-33)(human) has anti-obesity effect[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CRFR

Research Areas >> Neurological Disease

[References]

[1]. S C Heinrichs, et al. Dissociation of arousal-like from anxiogenic-like actions of brain corticotropin-releasing factor receptor ligands in rats. Behav Brain Res. 2001 Jul;122(1):43-50.

[2]. S C Heinrichs, et al. Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Physiol Behav. 2001 Sep 1-15;74(1-2):5-13.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄₁H₂₃₁N₄₁O₄₃S

[ Molecular Weight ]:
3220.66000

[ Exact Mass ]:
3218.69000

[ PSA ]:
1394.64000

[ LogP ]:
3.96850

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders.

Mol. Psychiatry 1 , 265-277, (1996)

The actions of CRF in the brain and in the periphery are mediated through multiple binding sites. There are three receptors, CRF1, CRF2 alpha and CRF2 beta, which encode 411, 415 and 431 amino acid pr...

Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine withdrawal.

Proc. Natl. Acad. Sci. U. S. A. 93 , 15475-15480, (1996)

Elevation of the neuropeptide corticotropin-releasing factor (CRF) in the brain is associated with a reduction of food intake and body weight gain in normal and obese animals. A protein that binds CRF...