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Ralaniten

Names

[ CAS No. ]:
1203490-23-6

[ Name ]:
Ralaniten

[Synonym ]:
(2R)-3-[4-(2-{4-[(2S)-3-Chloro-2-hydroxypropoxy]phenyl}-2-propanyl)phenoxy]-1,2-propanediol
1,2-Propanediol, 3-[4-[1-[4-[(2S)-3-chloro-2-hydroxypropoxy]phenyl]-1-methylethyl]phenoxy]-, (2R)-
WC830G6O4X
MFCD30502912

Biological Activity

[Description]:

Ralaniten (EPI-506) is a novel small-molecule inhibitor of androgen receptor (AR) N-terminal domain inhibitor for the treatment of advanced prostate cancer; AR NTD-targeting agents have the potential to overcome shortcomings of current hormonal therapies by inhibiting all forms of AR-mediated transcriptional activity, and as a result, may affect a broader AR population including mutational and splice variant ARs. Prostate Cancer Phase 2 Clinical

[References]

References 1. Antonarakis ES, et al. Oncologist. 2016 Dec;21(12):1427-1435. View Related Products by Target Estrogen Receptor/ERR Prostate Cancer

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
601.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H27ClO5

[ Molecular Weight ]:
394.889

[ Flash Point ]:
317.2±31.5 °C

[ Exact Mass ]:
394.154694

[ LogP ]:
2.98

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.571

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds