VGSCs-IN-1

Names

[ CAS No. ]:
1204296-79-6

[ Name ]:
VGSCs-IN-1

Biological Activity

[Description]:

VGSCs-IN-1 (compound 14), a 2-piperazine analog of Riluzole (HY-B0211), is a human voltage-gated sodium channels (VGSCs) inhibitor. VGSCs-IN-1 shows great Nav1.4 blocking activity. VGSCs-IN-1 has a pKa of 7.6 and a cLog P of 2.4. VGSCs-IN-1 can be used for cell excitability disorders research[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

[Target]

hNav1.4

hNav1.7

[References]

[1]. Farinato A, et al. Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels. ACS Med Chem Lett. 2023 Jun 23;14(7):999-1008.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₂F₃N₃OS

[ Molecular Weight ]:
303.30

[ Exact Mass ]:
303.06500

[ PSA ]:
65.63000

[ LogP ]:
2.99830