VIP (1-12), human, porcine, rat, ovine

Names

[ CAS No. ]:
120928-03-2

[ Name ]:
VIP (1-12), human, porcine, rat, ovine

[Synonym ]:
vip 1-12
VASOACTIVE INTESTINAL PEPTIDE FRAGMENT 1-12 HUMAN,PORCINE,RAT
HSDAVFTDNYTR
vasoactive intestinal peptide fragment*1-12 human

Biological Activity

[Description]:

VIP (1-12), human, porcine, rat, ovine is a vasoactive intestinal peptide (VIP) fragment. VIP (1-12), human, porcine, rat, ovine is a ligand for the CD4 (T4)/human immunodeficiency virus receptor[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[In Vivo]

VIP (1-12), human, porcine, rat, ovine (1-10 μg; ICV) 导致大鼠被动回避反应的记忆障碍[1]。 Animal Model: Male Wistar rats (250 g)[1] Dosage: 1, 2.5, 5, 10 μg Administration: Intracerebroventrical injection Result: Caused a dose-dependent decrease in the response.

[References]

[1]. Takashima A, et, al. Vasoactive intestinal peptide (VIP) causes memory impairment in passive avoidance responding of the rat. Peptides. 1993 Oct;14(5):1067-71.

[2]. Sacerdote P, et, al. Vasoactive intestinal peptide 1-12: a ligand for the CD4 (T4)/human immunodeficiency virus receptor. J Neurosci Res. 1987;18(1):102-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₁H₈₈N₁₈O₂₂

[ Molecular Weight ]:
1425.46000

[ Exact Mass ]:
1424.63000

[ PSA ]:
672.61000

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

The entire vasoactive intestinal polypeptide molecule is required for the activation of the vasoactive intestinal polypeptide receptor: functional and binding studies on opossum internal anal sphincter smooth muscle.

J. Pharmacol. Exp. Ther. 266 , 392-399, (1993)

Because no significant information exists regarding the structure-activity of vasoactive intestinal polypeptide (VIP) to gut smooth muscle, we performed functional studies in vitro on opossum internal...

Mechanisms of vasodilation elicited by VIP in sterically stabilized liposomes in vivo.

Am. J. Physiol. 273 , R287-292, (1997)

The purpose of this study was to begin to determine the mechanisms underlying vasodilation elicited by vasoactive intestinal peptide (VIP) in sterically stabilized liposomes (SSL) in the in situ perip...

Vasoactive intestinal peptide 1-12: a ligand for the CD4 (T4)/human immunodeficiency virus receptor.

J. Neurosci. Res. 18 , 102, (1987)

A five-amino-acid (TDNYT) sequence of vasoactive intestinal polypeptide (VIP) shares homology with the proposed attachment sequences of the human immunodeficiency virus (HIV). Synthetic peptides with ...