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IEM-1460

Names

[ CAS No. ]:
121034-89-7

[ Name ]:
IEM-1460

[Synonym ]:
5-[(Adamantan-1-ylmethyl)amino]-N,N,N-trimethyl-1-pentanaminium bromide hydrobromide (1:1:1)
1-Pentanaminium, N,N,N-trimethyl-5-[(tricyclo[3.3.1.1]dec-1-ylmethyl)amino]-, bromide, hydrobromide (1:1:1)
5-[(Adamantan-1-ylmethyl)amino]-N,N,N-trimethylpentan-1-aminium bromide hydrobromide (1:1:1)
Iem 1460
Tocris-1636

Biological Activity

[Description]:

IEM-1460 blocks both AMPA and NMDA glutamate receptor with anticonvulsant effect in vivo[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Schlesinger F, et al. Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors. Br J Pharmacol. 2005 Jul;145(5):656-63.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H38Br2N2

[ Molecular Weight ]:
454.33

[ Exact Mass ]:
452.140167

[ PSA ]:
12.03000

[ LogP ]:
2.02190

Related Compounds