methylcyclopentadienylmanganese tricarbonyl

MOLECULAR FORMULA :

C9-H7-Mn-O3

MOLECULAR WEIGHT :

218.10

WISWESSER LINE NOTATION :

L5J A1-MN-VHVHVH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 30,168,1975 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

8 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976 Volume(issue)/page/year: -,-,1976

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

76 mg/m3/4H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 40,164,1979

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

665 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976 Volume(issue)/page/year: -,-,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

12 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - hemorrhage

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 39,1,1987

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

34 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NICHAS Nichidai Igaku Zasshi. Nihon University Medical Journal. (Nihon Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan) V.1- 1937- Volume(issue)/page/year: 44,173,1985

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

58600 ug/m3/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 20,553,1978

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

152 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

SKIZAB Shikoku Igaku Zasshi. Shikoku Medical Journal. (Tokushima Igakkai, Tokushima Daigaku Igakubu, Kuramoto-cho, Tokushima 770, Japan) V.1- 1950- Volume(issue)/page/year: 34,183,1978

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

620 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976 Volume(issue)/page/year: -,-,1976

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

489 mg/m3/2H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976 Volume(issue)/page/year: -,-,1976

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

10 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976 Volume(issue)/page/year: -,-,1976

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

223 mg/m3/7H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976 Volume(issue)/page/year: -,-,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

95 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976 Volume(issue)/page/year: -,-,1976

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

411 mg/m3/7H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976 Volume(issue)/page/year: -,-,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

140 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 40,164,1979

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

6600 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976 Volume(issue)/page/year: -,-,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

905 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976 Volume(issue)/page/year: -,-,1976

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

411 mg/m3/7H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976 Volume(issue)/page/year: -,-,1976 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

75426 mg/kg/1Y-I

REFERENCE :

AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 23,473,1992 *** REVIEWS *** ACGIH TLV-TWA 0.2 mg(Mn)/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433) Volume(issue)/page/year: TR-73-125,1973 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Mn,126,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.1 ppm (0.2 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,164,1971 OSHA PEL (Shipyard):CL 5 mg(Mn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.2 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.2 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.2 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 0.2 mg/m3;STEL 0.6 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 0.2 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.2 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 9.2 mg/m3;STEL 0.6 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO THE CHEMICAL-air:10H TWA 0.2 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84547 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 34 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84547 No. of Facilities: 65 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 4891 (estimated)