EGFR/HER2-IN-2

Names

[ CAS No. ]:
1215571-02-0

[ Name ]:
EGFR/HER2-IN-2

Biological Activity

[Description]:

EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual inhibitor of EGFR and HER2 with IC50 values of 5.02 µM and 0.83 µM against EGFR and HER2, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR:5.02 μM (IC50)

HER2:0.83 μM (IC50)


[References]

[1]. Sangande, et al. 2-substituted 4-aminoquinazoline derivatives as potential dual inhibitors of EGFR and HER2: an in silico and in vitro study. Medicinal Chemistry Research 31.5 (2022): 762-771.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H23N5O3

[ Molecular Weight ]:
453.49

Related Compounds