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Linalool-d3

Names

[ CAS No. ]:
1216673-02-7

[ Name ]:
Linalool-d3

[Synonym ]:
3,7-Dimethyl(1,1,2-H)-1,6-octadien-3-ol
Linalool(1,1,2-D3)
(±)-Linalool-d3 (vinyl-d3)
3,7-Dimethyl(1,1,2-H)octa-1,6-dien-3-ol
1,6-Octadien-1,1,2-d-3-ol, 3,7-dimethyl-

Biological Activity

[Description]:

Linalool-d3 is the deuterium labeled Linalool[1]. Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity[2].Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome[3].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Oner Z1, et al. The protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino rats. Hum Exp Toxicol. 2019 Apr 12:960327119842634.  

[3]. Jun HJ, et al. Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun55(6):1098-110.  

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
198.5±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H15D3O

[ Molecular Weight ]:
157.268

[ Flash Point ]:
76.1±0.0 °C

[ Exact Mass ]:
157.154602

[ LogP ]:
3.28

[ Vapour Pressure ]:
0.1±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.463

Related Compounds