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ICI-118551

Names

[ CAS No. ]:
1217094-53-5

[ Name ]:
ICI-118551

[Synonym ]:
3-(Isopropylamino)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-2-butanol hydrochloride (1:1)
MFCD00153812
2-Butanol, 1-[(2,3-dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-, hydrochloride (1:1)
3-(Isopropylamino)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]butan-2-ol hydrochloride (1:1)
ICI-118551 HYDROCHLORIDE

Biological Activity

[Description]:

(Rac)-ICI-118551 hydrochloride is a selective β2-adrenergic receptor antagonist. (Rac)-ICI-118551 hydrochloride can inhibit dendrite ramification of hippocampal neurons in a mouse model of Alzheimer's disease[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Neurological Disease

[References]

[1]. Wu Q, et, al. Blocking beta 2-adrenergic receptor inhibits dendrite ramification in a mouse model of Alzheimer's disease. Neural Regen Res. 2017 Sep;12(9):1499-1506.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H28ClNO2

[ Molecular Weight ]:
313.86

[ Exact Mass ]:
313.180847

[ Storage condition ]:
-20℃

Related Compounds