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Galnon (trifluoroacetate salt)

Names

[ CAS No. ]:
1217448-19-5

[ Name ]:
Galnon (trifluoroacetate salt)

[Synonym ]:
3-Cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide trifluoroacetate (1:1)
Galnon (trifluoroacetate salt)
7-((9-Fluorenylmethoxycarbonyl)cyclohexylalanyllysyl) amino-4-methylcoumarin trifluoroacetate salt
MFCD06798339
Galnon trifluoroacetate salt
Acetic acid, 2,2,2-trifluoro-, compd. with L-lysinamide, 3-cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- (1:1)

Biological Activity

[Description]:

Galnon TFA is a selective and non-peptide agonist of galanin GAL1 and GAL2 receptor, with Kis of 11.7 and 34.1 μM respectively. Galnon TFA exhibits anticonvulsant and anxiolytic effects[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[References]

[1]. Bartfai T, et, al. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10470-5.  

[2]. Rajarao SJR, et, al. Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon. Neuropeptides. 2007 Oct;41(5):307-20.  

Chemical & Physical Properties

[ Molecular Formula ]:
C42H47F3N4O8

[ Molecular Weight ]:
792.840

[ Exact Mass ]:
792.334595

Related Compounds