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Fumonisin B1-13C34

Names

[ CAS No. ]:
1217458-62-2

[ Name ]:
Fumonisin B1-13C34

[Synonym ]:
EINECS 808-555-8

Biological Activity

[Description]:

Fumonisin B1-13C34 is the 13C labeled Fumonisin B1 (HY-N6719)[1]. Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin[2][3].

[Related Catalog]:

Research Areas >> Infection

[Target]

Sphingosine N-acyltransferase[2]


[In Vitro]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 Fumonisin B1 改变猴肾细胞基因表达和信号转导通路[2]。 Fumonisin B1 增加鞘脂代谢的初始破坏和鞘氨醇在 LLC-PK1 肾细胞中的积累，导致大鼠星形胶质细胞凋亡型 DNA 损伤[2]。

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

Chemical & Physical Properties

[ Molecular Formula ]:
13C34H59NO15

[ Flash Point ]:
2 °C

[ Storage condition ]:
−20°C

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H312 + H332-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338

[ Hazard Codes ]:
F,Xn

[ Risk Phrases ]:
11-20/21/22-36

[ Safety Phrases ]:
26-36/37-16

[ RIDADR ]:
UN 1648 3/PG 2

Related Compounds