N-Methyl duloxetine-d7

Names

[ CAS No. ]:
1217657-97-0

[ Name ]:
N-Methyl duloxetine-d7

Biological Activity

[Description]:

N-Methyl duloxetine-d7 is the deuterium labeled N-Methyl Duloxetine. N-Methyl Duloxetine is an analgesic. N-Methyl Duloxetine elicits both tonic and use-dependent block of neuronal Na+ channels[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Wang CF, et al. R-Duloxetine and N-Methyl Duloxetine as Novel Analgesics Against ExperimentalPostincisional Pain. Anesth Analg. 2016 Mar;122(3):719-29.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H14D7NOS

[ Molecular Weight ]:
318.48

Related Compounds