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5-Iodo-A-85380 dihydrochloride

Names

[ CAS No. ]:
1217837-17-6

[ Name ]:
5-Iodo-A-85380 dihydrochloride

[Synonym ]:
3-[(2S)-Azetidin-2-ylmethoxy]-5-iodopyridine dihydrochloride
Pyridine, 3-[(2S)-2-azetidinylmethoxy]-5-iodo-, hydrochloride (1:2)
3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridine dihydrochloride
MFCD03791315

Biological Activity

[Description]:

5-Iodo-A-85380 dihydrochloride is a selective ligand of nAChR. 5-Iodo-A-85380 dihydrochloride binds to α4β2 nAChRs in rat and human brain with Kds of 12 and 14 pM,respectively[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease

[References]

[1]. Mukhin AG, et al. 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol. 2000 Mar;57(3):642-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C9H13Cl2IN2O

[ Molecular Weight ]:
363.023

[ Exact Mass ]:
361.944946

Related Compounds