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N-Nitrosodi-n-butylamine-d18

Names

[ CAS No. ]:
1219798-82-9

[ Name ]:
N-Nitrosodi-n-butylamine-d18

Biological Activity

[Description]:

N-Nitrosodibutylamine-d18 is the deuterium labeled N-Nitrosodibutylamine[1]. N-Nitrosodibutylamine (N-Nitroso-di-n-butylamine) is a nitrosamine enriched in the drinking water[2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Chao Zhao, et al. Distribution of N-nitrosamines in Drinking Water and Human Urinary Excretions in High Incidence Area of Esophageal Cancer in Huai'an, China. Chemosphere. 2019 Nov;235:288-296.  

Chemical & Physical Properties

[ Molecular Formula ]:
C8D18N2O

[ Molecular Weight ]:
176.352232004

[ Appearance of Characters ]:
Oil | Colourless to Yellow

[ Storage condition ]:
Amber Vial, Refrigerator, Under inert atmosphere

[ Stability ]:
Light Sensitive

[ Water Solubility ]:
Chloroform (Slightly), Methanol (Slightly)

Related Compounds