(±)-Anatoxin A fumarate

Names

[ CAS No. ]:
1219922-30-1

[ Name ]:
(±)-Anatoxin A fumarate

[Synonym ]:
Ethanone, 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-, (2E)-2-butenedioate (1:1)
1-(9-Azabicyclo[4.2.1]non-2-en-2-yl)ethanone (2E)-2-butenedioate (1:1)

Biological Activity

[Description]:

(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM)[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[Target]

Ki: 1.25 nM ( α4β2 receptor) Ki: 1.84 μM ( α7 receptor)[1]

[References]

[1]. P Thomas, et al. (+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors. J Neurochem. 1993 Jun;60(6):2308-11.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₉NO₅

[ Molecular Weight ]:
281.304

[ Exact Mass ]:
281.126312

[ PSA ]:
103.70000

[ LogP ]:
1.45680

(±)-Anatoxin A fumarate

Names

Biological Activity

Chemical & Physical Properties

Related Compounds