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TC-I 2014

Names

[ CAS No. ]:
1221349-53-6

[ Name ]:
TC-I 2014

Biological Activity

[Description]:

TC-I 2014 (compound 5) is a potent Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel
Research Areas >> Neurological Disease

[Target]

TRPM8[1].


[References]

[1]. Parks DJ, et Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem. 2011 Jan 13;54(1):233-47.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H19F6N3O

[ Molecular Weight ]:
467.41

Related Compounds