2-Methyl-3-(4-Trifluoromethoxyphenyl)Benzoic Acid

Names

[ Name ]:
2-Methyl-3-(4-Trifluoromethoxyphenyl)Benzoic Acid

[Synonym ]:
2-methyl-3-[4-(trifluoromethoxy)phenyl]benzoic acid

Biological Activity

[Description]:

Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer Tmax (60 h) than Sonidegib[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Markus Zollinger, et al. Absorption, distribution, metabolism, and excretion (ADME) of ¹⁴C-sonidegib (LDE225) in healthy volunteers. Cancer Chemother Pharmacol. 2014 Jul;74(1):63-75.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₁F₃O₃

[ Molecular Weight ]:
296.24100

[ Exact Mass ]:
296.06600

[ PSA ]:
46.53000

[ LogP ]:
4.25880

MSDS

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Safety Information

[ HS Code ]:
2918990090

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%