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BMS-933043

Names

[ CAS No. ]:
1221973-93-8

[ Name ]:
BMS-933043

[Synonym ]:
Spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine, N-[6-(1H-imidazol-1-yl)-4-pyrimidinyl]-
N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-amine

Biological Activity

[Description]:

BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively; displays high selectivity against other nAChR subtypes (>100-fold) and 5-HT3A receptor (>300-fold); demonstrates in vivo activity in a preclinical model of cognitive impairment, mouse novel object recognition. Schizophrenia Phase 1 Discontinued

[References]

References 1. King D, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):366-371. 2. Bristow LJ, et al. PLoS One. 2016 Jul 28;11(7):e0159996. 3. Weed MR, et al. PLoS One. 2017 Dec 19;12(12):e0187609. View Related Products by Target nAChR Schizophrenia

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
539.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H19N7O

[ Molecular Weight ]:
325.368

[ Flash Point ]:
279.9±32.9 °C

[ Exact Mass ]:
325.165100

[ LogP ]:
0.27

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.815

Related Compounds