Trichostatin A S-isomer

Names

[ Name ]:
Trichostatin A S-isomer

[Synonym ]:
.TSA
.(R)-trichostatin A
.(R)-(+)-trichostatin A
.(7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide)
(+)-TSA

[Description]:

(S)-Trichostatin A ((S)-TSA) 是一种 HDAC6 选择性抑制剂，对斑马鱼 HDAC6 和人 HDAC6 的 IC50 值分别为 9.88 nM和 11.1 nM。(S)-Trichostatin A 弱抑制其他人 HDAC。

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[Target]

hHDAC6:11.1 nM (IC50)

Zebrafish HDAC6:9.88 nM (IC50)

hHDAC1:206.3 nM (IC50)

hHDAC2:612.65 nM (IC50)

hHDAC3:320.8 nM (IC50)

hHDAC4:6341 nM (IC50)

hHDAC5:6325 nM (IC50)

hHDAC7:1823.5 nM (IC50)

hHDAC8:312.2 nM (IC50)

hHDAC9:4824 nM (IC50)

hHDAC10:403.35 nM (IC50)

hHDAC11:2684 nM (IC50)

[References]

[ Molecular Formula ]:
C₁₇H₂₂N₂O₃

[ Molecular Weight ]:
302.36800

[ Exact Mass ]:
302.16300

[ PSA ]:
69.64000

[ LogP ]:
2.97020