<Suppliers Price>

Mivobulin

Names

[ CAS No. ]:
122332-18-7

[ Name ]:
Mivobulin

[Synonym ]:
MIVOBULIN
mivobulin isethionate
UNII-96U5LG549X

Biological Activity

[Description]:

Mivobulin (NSC 613862) is a tubulin inhibitor, binds to tubulin in the region that overlaps the colchicine site, and inhibits tubulin polymerization. Mivobulin (NSC 613862) promotes the formation of abnormal polymers and a GTPase activity in the tubulin dimer. Anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Tubulin[1]


[References]

[1]. Barbier P, et al. The active GTP- and ground GDP-liganded states of tubulin are distinguished by the binding of chiral isomers of ethyl 5-amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl carbamate. Biochemistry. 1998 Jan 13;37(2):758-68.

Chemical & Physical Properties

[ Density]:
1.36

[ Boiling Point ]:
483ºC at 760mmHg

[ Molecular Formula ]:
C17H19N5O2

[ Molecular Weight ]:
315.40700

[ Flash Point ]:
245.9ºC

[ Exact Mass ]:
315.18300

[ PSA ]:
57.61000

[ LogP ]:
2.90650

[ Vapour Pressure ]:
1.74E-09mmHg at 25°C

[ Index of Refraction ]:
1.671

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds