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D-Lin-MC3-DMA

Names

[ CAS No. ]:
1224606-06-7

[ Name ]:
D-Lin-MC3-DMA

[Synonym ]:
(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
(6Z,9Z,28Z,31Z)-heptatriaonta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
dilinoleylmethyl 4-(dimethylamino)butanoate
(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate
heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate
(6Z,9Z,28Z,31Z)heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate
D-Lin-MC3-DMA

Biological Activity

[Description]:

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer

[In Vivo]

Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizableamino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. LNP-siRNA systems optimize to achieve maximum gene silencing potency in hepatocytesfollowing IV administration in mice contain DLin-MC3-DMA (MC3), DSPC, cholesterol and a polyethyleneglycol (PEG)-lipid at mole ratios of 50/10/38.5/1.5. DLin-MC3-DMA exhibits an optimized pKa value that leads to dramatically enhanced potency[1].

[References]

[1]. Kulkarni JA, et al. Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. Nanomedicine. 2017 May;13(4):1377-1387.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
0.886±0.06 g/cm3(Predicted)

[ Boiling Point ]:
670.2±43.0 °C(Predicted)

[ Molecular Formula ]:
C43H79NO2

[ Molecular Weight ]:
642.09300

[ Exact Mass ]:
641.61100

[ PSA ]:
29.54000

[ LogP ]:
13.64720

[ Storage condition ]:
-20℃

Related Compounds